郭丽琼
职称：副研究员
邮箱：guoliqiong@tju.edu.cn; yingqidao@163.com
电话：022-87370177-317
地址：天津大学10号东配楼应急医学研究院317办公室
郭丽琼，天津大学应急医学院副研究员，天津大学温州安全（应急）研究院科研部/实验中心主任。美国哈佛大学联合培养博士，硕士生导师，华中科技大学客座教授，天津市科技创新人才青年科技优秀人才，天津市“131″创新型人才培养计划第三层次人才。天津市医学会罕见病分会委员，天津市医学会医学遗传学分会委员，天津市预防医学会血管疾病预防分会委员。担任国际多个相关领域杂志审稿人。主持国家自然科学基金两项，省部级基金项目两项，局级基金项目一项，转化项目一项，参与多项国家级和省部级基金项目，发表SCI论文40余篇。授权专利三项。
教育背景
2010/09-2014/12，南开大学，环境科学与工程学院环境科学系，理学博士
2011/09-2013/04，美国哈佛大学，公共卫生学院环境卫生系，联合培养博士
2007/09-2010/06，华中农业大学，动物医学院预防兽医学专业，农学硕士
2003/09-2007/06, 华中农业大学，生命科学与技术学院生物科学专业，理学学士
工作经历
2020/06-至今，天津大学应急医学研究院，副研究员，硕士生导师
2015/07-2020/04，天津医科大学公共卫生学院，讲师
社会学术兼职
天津医学会罕见病分会委员
天津市医学会医学遗传学分会委员
天津市预防医学会血管疾病预防分会委员
国际SCI期刊Frontiers in Genetics杂志编委成员
Environmental Pollution, Science of the Total Environment和Environmental Research等多个相关领域杂志审稿人
人才情况
天津市创新人才推进计划青年科技优秀人才
天津市“131”创新型人才培养计划第三层次人才
主要研究方向
体外诊断技术研究、疾病风险预测、灾难分子流行病学，环境表观流行病学，表观遗传学
代表性学术成果
【代表性论文】
1. Ziquan Liu#, Xuemei Chen#, Huanhuan Cui, Yuxuan Ma, Ning Gao, Xinyu Li, Xiangyan Meng, Huishu Lin, Halidan Abudou, Liqiong Guo*, Qisijing Liu*. Green space exposure on depression and anxiety outcomes: A meta-analysis. Environmental Research, 2023,231,116303.
2. Weixia Li#, Liqiong Guo#, Junkai Fang, Lei Zhao, Shanjun Song, Tao Fang, Chenguang Li, Lei Wang*, Penghui Li*. Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation. Frontiers Public Health, 2023,11:1108555.
3. Jing Wu, Yong Liu, Lijun Peng, Qisijing Liu, Dawei Wang, Xu Jing, Yaozhong Hu, Jing Lin, Hanyue Fu, Xuemeng Ji, Jingmin Liu, Huan Lv, Bo Peng, Bowei Zhang, Liqiong Guo*, Shuo Wang*. A Plasmonic Fluor-lightened Microneedle Array Enables Ultrasensitive Multitarget Whole Blood Diagnosis of Anemia in A Paper Origami-based Device. Small, 2023, e2300464.
4. Yaning Jia#, Weixia Li#, Yanlin Li, Lei Zhao, Chenguang Li, Lei Wang, Junkai Fang, Shanjun Song, Yaqin Ji, Tao Fang, Jing Zhang, Liqiong Guo*, Penghui Li*. The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers. Toxics, 2023, 11(5):466.
5. Juan Chen#, Liqiong Guo#, Huimeng Liu, Lei Jin, Wenying Meng, Junkai Fang, Lei Zhao, Xiao-Wen Zeng, Bo-Yi Yang, Qi Wang, Xinbiao Guo, Furong Deng, Guang-Hui Dong, Xuejun Shang*, Shaowei Wu*. Modification effects of ambient temperature on associations of ambient ozone exposure before and during pregnancy with adverse birth outcomes: A multicity study in China. Environment International, 2023, 172:107791.
6. Liqiong Guo#, Huishu Lin#, Hongyu Li, Xiaobin Jin, Lei Zhao, Penghui Li, Naiwei Xu, Song Xu, Junkai Fang, Shaowei Wu*, Qisijing Liu*. Exposure of ambient PM2.5 during gametogenesis period affects the birth outcome: results from the project ELEFANT. Environmental Research, 2023, 220:115204.
7. Huishu Lin, Qisijing Liu, Lei Zhao, Ziquan Liu, Huanhuan Cui, Penghui Li, Haojun Fan* and Liqiong Guo*. Circulating Pulmonary-Originated Epithelial Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2023, 24, 6090.
8. Qisijing Liu#, Jing Wang#, Chixuan Yao#, Lu Yang, Lei Zhao, Liqiong Guo, Jing-Min Liu, Shuo Wang*. Functional micro-/nanostructures in agrofood science: precise inspection, hazard elimination, and potential health risks. Journal of Agricultural and food chemistry, 2023, 71(2):1018-1034.
9. Liqiong Guo#, Yanhua Wang#, Xueli Yang, Ting Wang, Jingjing Yin, Lei Zhao, Yang Lin, Yufei Dai, Shike Hou*, Huawei Duan*. Aberrant mitochondrial DNA methylation and declined pulmonary function in a population with polycyclic aromatic hydrocarbon composition in particulate matter. Environmental Research, 2022, 214: 113797.
10. Liqiong Guo#, Ziquan Liu#, Penghui Li*, Yaqin Ji*, Shanjun Song, Na Zheng, Lei Zhao, Yaning Jia, Junkai Fang, Huiyu Wang, Hyang-Min Byun. Association between mitochondrial DNA methylation and internal exposure to polycyclic aromatic hydrocarbons (PAHs), nitrated-PAHs (NPAHs) and oxygenated-PAHs (OPAHs) in young adults from Tianjin, China. Ecotoxicology and Environmental Safety, 2022, 241: 113799.
11. Jing Zhang#, Ziquan Liu#, Shanjun Song, Junkai Fang, Lei Wang, Lei Zhao, Chenguang Li, Weixia Li, Hyang-Min Byun, Liqiong Guo*, Penghui Li*. The exposure levels and health risk assessment of antibiotics in urine and its association with platelet mitochondrial DNA methylation in adults from Tianjin, China: A preliminary study. Ecotoxicology and Environmental Safety, 2022, 231: 113204.
12. Juan Chen#, Peng-Hui Li#, Haojun Fan, Chen Li, Ying Zhang, Duan Ju, Furong Deng, Xinbiao Guo, Liqiong Guo*, Shaowei Wu*. Weekly-specific ambient fine particular matter exposures before and during pregnancy were associated with risks of small for gestational age and large for gestational age: results from Project ELEFANT. International Journal of Epidemiology, 2022, 51(1):202-212.
13. Xinying Shui#, Lei Zhao#, Wenli Li, Yaning Jia, Ziquan Liu, Chen Li, Xueli Yang, Haoran Huang, Shouling Wu, Shuohua Chen, Jingli Gao, Xiaolan Li, Aitian Wang, Xiaobin Jin, Liqiong Guo*, Shike Hou*. Association between exposure to earthquake in early life and diabetes mellitus incidence in adulthood with the modification of lifestyles: Results from the Kailuan study. Frontiers in Pediatrics, 2022, 10:1046086.
14. Juan Chen, Shaowei Wu, Junkai Fang, Ziquan Liu, Xuejun Shang, Xinbiao Guo, Furong Deng*, Liqiong Guo*. Association of exposure to fine particulate matter wave over the preconception and pregnancy periods with adverse birth outcomes: Results from the project ELEFANT. Environmental Research, 2021, 205:112473.
15. Ziquan Liu#, Huanhuan Cui#, Lei Zhao, Fucai Ma, Yanqing Liu, Yuansen Chen, Jiale Chen, Yaning Jia, Wenli Li, Jinxia Cai, Xun Bi, Penghui Li, Haojun Fan, Liqiong Guo*, Shike Hou*. Effects of plateau air quality and low oxygen content on platelet mtdna methylation and high altitude pulmonary edema. Aerosol and Air Quality Research, 2021, 21(12):210222.
16. Bibo Yuan#, Citlalli Osorio-Yáñez#, Junkai Fang, Lei Zhao, Ander Wilson, Marco Sanchez-Guerra, Hongbin Liu, Peng-Hui Li*, Liqiong Guo*. Effect of Radiation, Organic Solvents and Vibration Occupational Exposure on the Thyroid Disease: Results from Project ELEFANT. Aerosol and Air Quality Research, 2021, 21(9), 210085.
17. Qisijing Liu, Hongyu Li, Liqiong Guo, Qiao Chen, Xu Gao, Peng-hui Li, Naijun Tang, Xinbiao Guo, Furong Deng*, Shaowei Wu*. Effects of short-term personal exposure to air pollution on platelet mitochondrial DNA methylation levels and the potential mitigation by L-arginine supplementation. Journal of Hazardous Materials, 2021, 417:125963.
18. Duan Ju, Xiaozhou Li, Yunfang Shi, Yanhong Ma, Liqiong Guo, Yanli Wang, Ruiyu Ma, Yuanyue Zhong, Ying Zhang*, Fengxia Xue*. Evaluation of the practical applications of fluorescence in situ hybridization in the prenatal diagnosis of positive noninvasive prenatal screenings. The Journal of Maternal-Fetal & Neonatal Medicine. 2021, 417: 125963.
19. Lei Zhao, Shanjun Song, Penghui Li*, Jing Liu, Jing Zhang, Lei Wang, Yaqin Ji, Jinpeng Liu*, Liqiong Guo, Jinbao Han. Fine particle-bound PAHs derivatives at mountain background site (Mount Tai) of the North China: Concentration, source diagnosis and health risk assessment. Journal of Environmental Sciences, 2021, 109: 77-87.
20. Juan Chen, Junkai Fang, Ying Zhang, Zhouyang Xu, Hyang-Min Byun, Peng-hui Li, Furong Deng, Xinbiao Guo, Liqiong Guo*, Shaowei Wu*. Associations of adverse pregnancy outcomes with high ambient air pollution exposure: Results from the Project ELEFANT. Science of the Total Environment, 2021, 761, 143218.
21. Junkai Fang, Choong-Min Kang, Citlalli Osorio-Yáñez, Timothy M.Barrow, Ruiping Zhang, Ying Zhang, Chen Li, Hongbin Liu, Peng-hui Li, Liqiong Guo*, Hyang-Min Byun, Prenatal PM2.5 Exposure and the Risk of Adverse Births Outcomes: Results from Project ELEFANT. Environmental Research, 2020, 191, 110232.
22. Timothy M. Barrow, Cheng Peng, Ander Wilson, Hao Wang, Hongbin Liu, Lilin Shen, Nai-jun Tang, Chanachai Sae-Lee, Peng-hui Li, Liqiong Guo*, Hyang-Min Byun, Psychosocial stress is associated with benign breast disease in young Chinese women: results from Project ELEFANT. Breast Cancer Research and Treatment, 2019, 173: 217-224.
23. Peng-hui Li*, Hong-yan Jia, Yan Wang, Tao Li, Lei Wang, Qian-qian Li, Min-min Yang, Jun-jie Yue, Xian-liang Yi, Li-qiong Guo*, Characterization of PM2.5-bound phthalic acid esters (PAEs) at regional background site in northern China: Long-range transport and risk assessment. Science of the Total Environment, 2019, 659:140-149.
24. Liqiong Guo#*, Cheng Peng#, Hui Xu#, Ander Wilson, Peng-hui Li, Hao Wang, Hongbin Liu, Lilin Shen, Xi Chen, Xiuying Qi, Nai-jun Tang, Timothy M. Barrow, Hyang-Min Byun, Age at menarche and prevention of hypertension through lifestyle in young Chinese adult women: result from project ELEFANT. BMC Women's Health, 2018, 18: 182.
25. Hui Xu#, Peng-hui Li#, Timothy M. Barrow, Elena Colicino, Changping Li, Ruixue Song, Hongbin Liu, Nai-jun Tang, Songyan Liu, Liqiong Guo*, Hyang-Min Byun, Obesity as an effect modifier of the association between menstrual abnormalities and hypertension in young adult women: Results from Project ELEFANT. Plos One, 2018, 13(11): e0207929.
26. Liqiong Guo#*, Peng-hui Li, Hua Li, Elena Colicino, Silvia Colicina, Yi Wen, Ruiping Zhang, Xiaotian Feng, Timothy M. Barrow, Akin Cayir, Andrea A. Baccarelli, Hyang-Min Byun. Effect of environmental noise exposure on DNA methylation in the brain and metabolic health. Environmental Research. 2017; 153:73-82.
27. Timothy M. Barrow, Hyang-Min Byun, Xinyan Li, Chris Smart, Yong-Xiang Wang, Yacong Zhang, Andrea A. Baccarelli, Liqiong Guo*, The effect of morphine upon DNA methylation in ten regions of the rat brain. Epigenetics, 2017, 12: 1038-1047.
28. Liqiong Guo#*, Hyang-Min Byun, Jia Zhong, Valeria Motta, Jitendra Barupal, Yinan Zheng, Chang Dou, Feiruo Zhang, John P. McCracken, Anaité Diaz, Sanchez-Guerra Marco, Silvia Colicino, Joel Schwartz, Sheng Wang, Lifang Hou, Andrea A. Baccarelli. Effects of Short-term Exposure to Inhalable Particulate Matter on Tandem Repeats DNA Methylation. Environ Mol Mutagen, 2014. 55(4): 322-335.
29. Liqiong Guo#, Hongxiang Chen, Yongsheng Li, Qixing Zhou*, Yang Sui*. An Aquaporin 3-Notch Axis in Keratinocyte Differentiation and Inflammation. Plos One, 2013. 8(11): e80179.
30. Zhen Xu, Xiaodong Li, Dan Tian, Zhuoyu Sun, Liqiong Guo, Cuixia Dong, Naijun Tang, Hermine V. Mkrtchyan*. Molecular characterization of methicillin-resistant and -susceptible Staphylococcus aureus recovered from hospital personnel. Journal of medical microbiology. 2020, 69(12): 1332-1338.
31. Duan Ju, Xiao-Zhou Li, Yun-Fang Shi, Yan Li, Li-Qiong Guo, Ying Zhang*, Cytomegalovirus shedding in seropositive healthy women of reproductive age in Tianjin, China. Epidemiology and Infection, 2020, 148 (e34): 1-7.
32. Juan Liu, Hui-Yu Wang, Shan-Jun Song, Hui-Chun Ma, Wen-Tao Sun, Lei Wang*, Yan Wang, Xian-Liang Yi, Li-Qiong Guo, Peng-Hui Li*, Levels, potential sources and risk assessment of organochlorine pesticides in atmospheric particulate matter at regional background site. Aerosol and Air Quality Research, 2019, 19 (9), 2008-2016.
33. Akin Cayir*, Timothy M. Barrow, Liqiong Guo, Hyang-Min Byun. Exposure to environmental toxicants reduces global N6-methyladenosine RNA methylation and alters expression of RNA methylation modulator genes. Environmental Research. 2019, 175:228-234.
34. Peng-hui Li, Jie Yu, Cheng-liang Bi, Jun-jie Yue, Li Wang, Jinpeng Liu*, Zhimei Xiao, Liqiong Guo, Bi-jie Huang*. Health risk assessment for highway toll station workers exposed to PM2.5-bound heavy metals. Atmospheric Pollution Research. 2019, 10(4):1024-1030.
35. Na Zheng, Shanjun Song, Xinglong Jin, Hongyan Jia, Yan Wang, Yaqin Ji, Liqiong Guo, Penghui Li, Assessment of Carbonaceous Aerosols at Mount Tai, North China: Secondary Formation and Regional Source Analysis. Aerosol and Air Quality Research. 2019, 19: 1708-1720.
36. Juan Liu, Hui-Yu Wang, Shan-Jun Song, Hui-Chun Ma, Wen-Tao Sun, Lei Wang, Yan Wang, Xian-Liang Yi, Li-Qiong Guo, Peng-Hui Li, Levels, Potential Sources and Risk Assessment of Organochlorine Pesticides in Atmospheric Particulate Matter at Regional Background Site. Aerosol and Air Quality Research. 2019, 19: 2008-2016.
37. Octavio Jiménez-Garza#*, Liqiong Guo, Hyang-Min Byun, Mariella Carrieri, Giovanni Battista Bartolucci, Briscia Socorro Barrón-Vivanco, Andrea A. Baccarellie. Aberrant promoter methylation in genes related to hematopoietic malignancy in workers exposed to a VOC mixture. Toxicol Appl Pharmacol. 2018, 339: 65-72.
38. Octavio Jiménez-Garza#*, Liqiong Guo, Hyang-Min Byun, Mariella Carrieri, Giovanni Battista Bartolucci, Jia Zhong, Andrea A. Baccarellie. Promoter methylation status in genes related with inflammation, nitrosative stress and xenobiotic metabolism in low-level benzene exposure: Searching for biomarkers of oncogenesis. Food Chem Toxicol. 2017 Nov;109(Pt 1):669-676.
39. Hong-yan Jia, Lei Wang, Peng-hui Li*, Yan Wang*, Li-qiong Guo, Tao Li, Lei Sun, You-ping Shou, Tian-yu Mao, Xian-liang Yi, Characterization, long-Range transport and source identification of carbonaceous aerosols during spring and autumn periods at a high mountain site in south China. Atmosphere, 2016,7: atmos7100122.
40. Peng-Hui Li*, Yan Wang*, Tao Li, Lei Sun, Xianliang Yi, Li-qiong Guo, Rui-hong Su, Characterization of carbonaceous aerosols at Mount Lu in South China: implication for secondary organic carbon formation and long-range transport. Environment Science and Pollution Research, 2015, 22: 14189-14199.
41. Akin Cayir, Timothy M. Barrow, Hao Wang, Hongbin Liu, Changping Li, Ning Ding, Yan Li, Choong-Min Kang, Liqiong Guo, Peng-hui Li*, Hyang-Min Byun, Occupational noise exposure is associated with hypertension in China: Results from project ELEFANT. Plos One, 2018, 13(12): e0209041.
42. Yu-jie Zhao, You-ping Shou, Tian-yu Mao, Li-qiong Guo, Peng-hui Li*, Xianliang Yi, Qian-qian Li, Li-zhu Shen, Huan-rong Zuo, Jing Wang, Lei Wang. PAHs exposure assessment for highway toll station workers through personal particulate sampling and urinary biomonitoring in Tianjin, China. Polycyclic Aromatic Compounds, 2016, 38(4): 379-388.
43. Lifang Hou#*, Xiao Zhang#, Yinan Zheng, Sheng Wang, Chang Dou, Liqiong Guo, Hyang-Min Byun, Valeria Motta, John McCracken, Anaite Diaz, Choong-Min Kang, Petros Koutrakis, Pier Alberto Bertazzi, Jingyun Li, Joel Schwartz, Andrea A. Baccarelli. Altered Methylation in Tandem Repeat Element and Elemental Component Levels in Inhalable Air Particles. Environ Mol Mutagen, 2013. 55(3): 256-265.
44. Jun-Jie Yue, Roberta Palmiero, Yang-Yang Han, Yan Wang, Qian-Qian Li, Tuo-Yu Zhang, Meiqing Sun, Hong Wang, Guangping Yu, Xian-Liang Yi, Peng-Hui Li*, Ya-Qin Ji*, Li-Qiong Guo, Characterization of PM1-bound Metallic Elements in the Ambient Air at a High Mountain Site in Northern China. Aerosol and Air Quality Research, 2018, 18: 2967-2981.
45. Jing Liu, Yan Wang, Peng-Hui Li*, You-Ping Shou*, Tao Li, Min-Min Yang, Lei Wang, Jun-Jie Yue, Xian-Liang Yi, Li-Qiong Guo, Polycyclic Aromatic Hydrocarbons (PAHs) at High Mountain Site in North China: Concentration, Source and Health Risk Assessment. Aerosol and Air Quality Research, 2017, 17: 2867-2877.
46. 芮青妍; 李鑫; 张洪宝; 郭雪梅; 郑娜; 赵磊; 郭丽琼; 李彭辉; 岳俊杰*. 环境化学污染物暴露与表观遗传学之间关系的研究进展.中华劳动卫生职业病杂志, 2020, 38(3):237-240.
47. 陈娟; 徐洲阳; 邓芙蓉; 郭新彪; 郭丽琼*; 吴少伟*. 孕前和孕期大气NO_2暴露与小于胎龄儿和大于胎龄儿发生风险关联的易感暴露窗口识别. 环境与职业医学, 2022, 39(02):119-126.
48. 陈雪梅; 崔欢欢; 郭丽琼; 樊毫军; 刘子泉*. 高原肺冲击伤特点及救治研究进展. 中华灾害救援医学, 2022, 10(01): 26-29.
49. 刘子泉; 崔欢欢; 刘燕青; 郭丽琼; 孟祥艳; 赵艳梅; 柴慈婧; 毕珣*; 樊毫军*. 高原肺水肿的诊断、治疗与预防. 中华灾害救援医学, 2021, 9(08): 1162-1166.
【获得专利】
1.郭丽琼；刘子泉；李彭辉；董文龙；崔欢欢；赵磊；贾亚宁；樊毫军；侯世科；灾难模拟系统，2021-7-29，中国，实用新型专利，ZL202121736368.6
2.刘子泉；郭丽琼；丁辉；田学忠；刘越；刘燕青；樊毫军；侯世科；屈波；崔欢欢；陈原森；李文莉；蔡金霞；一种截肢手术箱，2021-2-23，中国，实用新型专利，ZL202120401938.X
3.刘子泉；樊毫军；刘燕青；郭丽琼；侯世科；孟祥艳；董文龙；崔欢欢；陈原森；李文莉；蔡金霞；球形动物高压舱，2021-2-4，中国，外观设计专利，ZL202130082513.2
【科研项目】
1.天津大学温州安全（应急）研究院科研转化项目，TJUWYY2023001，环境污染物与化学物质检测分析服务项目，2022/04-2025/01，1,000,000，在研，主持
2.天津大学温州安全（应急）研究院科研转化项目，TJUWYY2022019，基于线粒体表观遗传学的不良妊娠疾病预警技术研究，2022/01-2023/06, 1,000,000，在研，主持
3.国家自然科学基金面上项目，81971416，血小板mtDNA甲基化与不明原因复发性流产的巢式病例对照研究，2020/01-2023/12，550,000，在研，主持
4.天津大学资助创新基金，2021XZY-0076,作业能力监测维护与提升关键技术研究，2021/01-2021/12，30，000，已结题，主持
5. 国家自然科学基金青年基金，81602827，血小板mtDNA甲基化作为PM暴露的易感性生物标志物的探索性研究，2017/01-2019/12，180,000，已结题，主持
6.天津市自然科学基金青年基金，18JCQNJC11700,线粒体DNA甲基化作为PM2.5暴露致心血管疾病的新型生物标志物的研究，2018/04-2021/03，60,000，已结题，主持
7.天津医科大学基金，2010KY28，青年人群多环芳烃暴露的新型表观遗传标志物研究，2015/12-2017/11，10,000，已结题，主持
8.国家自然科学基金专项项目，81941024，基于遗传与环境交互作用调控线粒体功能对长寿的影响和机制研究，2020/01-2022/12，1,000,000，在研，参加；
9.国家自然科学基金面上项目，81872586，大气污染影响先天性心脏病发生的出生队列研究，2019/01-2022/12，570,000，在研，参加；
10.天津市科技计划项目，18ZXDBSY00190，基于新型标志物“不明原因复发性流产”风险预测模型的建立及评估——前瞻性队列研究，2018/10-2021/09,500,000，在研，参加；
11.国家自然科学基金青年基金，81602826， 出生前DEHP暴露对大鼠下丘脑能量平衡调控的影响及其机制研究，2017/01-2019/12，170,000，在研，参加；
12.国家自然科学基金青年基金，81602850，基于海马Notch信号通路的高脂饮食诱导认知障碍的机制研究，2017/01-2019/12，180,000，在研，参加；
13.国家自然科学基金青年基金，41601548，基于表观遗传学方法评估大气细颗粒物对人体心血管疾病的健康效应，2017/01-2019/12，190,000，在研，参加；
14.天津市自然科学基金青年基金，17JCQNJC10300,天津地区大气环境中有机磷酯阻燃剂的分布特征、来源解析及人群暴露风险评价研究，2017/04-2020/03，60,000，在研，参加；
