郭丽琼


职称:副研究员

邮箱:guoliqiong@tju.edu.cn; yingqidao@163.com

电话:022-27893596-317

地址:天津大学灾难医学研究院10号东配楼317

 

个人简介


理学博士,副研究员,硕士生导师。天津市创新人才推进计划青年科技优秀人才,天津市“131″创新型人才培养计划第三层次人才,天津医学会罕见病分会委员,北京环境诱变剂学会环境与健康青年委员会委员。主持国家自然科学基金面上项目、国家自然科学基金青年基金和天津市自然科学基金青年项目,参与多项国家级和省部级基金项目,发表SCI论文26篇。

教育背景


2010/09-2014/12,南开大学,环境科学与工程学院环境科学系,理学博士

2011/09-2013/04,美国哈佛大学,公共卫生学院环境卫生系,联合培养博士

2007/09-2010/06,华中农业大学,动物医学院预防兽医学专业,农学硕士2003/09-2007/06, 华中农业大学,生命科学与技术学院生物科学专业,理学学士 


研究方向


1、新型“高通量表观遗传学检测技术”平台的开发,对多种疾病(包括慢性病、重大性疾病)高风险人群和灾难现场人群进行疾病风险的预警和预测,并对后期的干预手段进行效果评估。

2、天津市队列人群构建和灾难流行病学队列构建与流行病学分析。与天津市多家医院和研究机构合作建立了天津市ELEFANT人群队列,被中国队列共享平台纳入(人群编号:CCC2018050801),使用分子流行病学手段对天津市人群队列进行疾病风险评估。


 

工作经历


2020/05-至今,天津大学,灾难医学研究院,副研究员,硕士生导师

2015/07-2020/04,天津医科大学,公共卫生学院,讲师 


代表性学术成果


【代表性论文】

(1) Juan Chen, Junkai Fang, Ying Zhang, Zhouyang Xu, Hyang-Min Byun, Peng-hui Li, Furong Deng, Xinbiao Guo, Liqiong Guo*, Shaowei Wu*. Associations of adverse pregnancy outcomes with high ambient air pollution exposure: Results from the Project ELEFANT. Science of the Total Environment, 2020. https://doi.org/10.1016/j.scitotenv.2020.143218. In press

(2) Junkai Fang, Choong-Min Kang, Citlalli Osorio-Yáñez, Timothy M.Barrow, Ruiping Zhang, Ying Zhang, Chen Li, Hongbin Liu, Peng-hui Li, Liqiong Guo*, Hyang-MinByun, Prenatal PM2.5 Exposure and the Risk of Adverse Births Outcomes: Results from Project ELEFANT. Environmental Research, 2020, 191, 110232

(3) Timothy M. Barrow, Cheng Peng, Ander Wilson, Hao Wang, Hongbin Liu, Lilin Shen, Nai-jun Tang, Chanachai Sae-Lee, Peng-hui Li, Liqiong Guo*, Hyang-Min Byun, Psychosocial stress is associated with benign breast disease in young Chinese women: results from Project ELEFANT. Breast Cancer Research and Treatment, 2019, 173: 217-224

(4) Peng-hui Li*, Hong-yan Jia, Yan Wang, Tao Li, Lei Wang, Qian-qian Li, Min-min Yang, Jun-jie Yue, Xian-liang Yi, Li-qiong Guo*, Characterization of PM2.5-bound phthalic acid esters (PAEs) at regional background site in northern China: Long-range transport and risk assessment. Science of the Total Environment, 2019, 659:140-149

(5) Liqiong Guo#*, Cheng Peng#, Hui Xu#, Ander Wilson, Peng-hui Li, Hao Wang, Hongbin Liu, Lilin Shen, Xi Chen, Xiuying Qi, Nai-jun Tang, Timothy M. Barrow, Hyang-Min Byun, Age at menarche and prevention of hypertension through lifestyle in young Chinese adult women: result from project ELEFANT. BMC Women's Health, 2018, 18: 182

(6) Hui Xu#, Peng-hui Li#, Timothy M. Barrow, Elena Colicino, Changping Li, Ruixue Song, Hongbin Liu, Nai-jun Tang, Songyan Liu, Liqiong Guo*, Hyang-Min Byun, Obesity as an effect modifier of the association between menstrual abnormalities and hypertension in young adult women: Results from Project ELEFANT. Plos One, 2018, 13(11): e0207929

(7) Liqiong Guo#*, Peng-hui Li, Hua Li, Elena Colicino, Silvia Colicina, Yi Wen, Ruiping Zhang, Xiaotian Feng, Timothy M. Barrow, Akin Cayir, Andrea A. Baccarelli, Hyang-Min Byun. Effect of environmental noise exposure on DNA methylation in the brain and metabolic health. Environmental Research. 2017; 153:73-82.

(8) Timothy M. Barrow, Hyang-Min Byun, Xinyan Li, Chris Smart, Yong-Xiang Wang, Yacong Zhang, Andrea A. Baccarelli, Liqiong Guo*, The effect of morphine upon DNA methylation in ten regions of the rat brain. Epigenetics, 2017, 12: 1038-1047

(9) Liqiong Guo#*, Hyang-Min Byun, Jia Zhong, Valeria Motta, Jitendra Barupal, Yinan Zheng, Chang Dou, Feiruo Zhang, John P. McCracken, Anaité Diaz, Sanchez-Guerra Marco, Silvia Colicino, Joel Schwartz, Sheng Wang, Lifang Hou, Andrea A. Baccarelli. Effects of Short-term Exposure to Inhalable Particulate Matter on Tandem Repeats DNA Methylation. Environ Mol Mutagen, 2014. 55(4): 322-335

(10) Liqiong Guo#, Hongxiang Chen, Yongsheng Li, Qixing Zhou*, Yang Sui*. An Aquaporin 3-Notch Axis in Keratinocyte Differentiation and Inflammation. Plos One, 2013. 8(11): e80179

(11) Akin Cayir*, Timothy M. Barrow, Liqiong Guo, Hyang-Min Byun. Exposure to environmental toxicants reduces global N6-methyladenosine RNA methylation and alters expression of RNA methylation modulator genes. Environ Res. 2019, 175:228-234.

(12) Peng-hui Li, Jie Yu, Cheng-liang Bi, Jun-jie Yue, Li Wang, Jinpeng Liu*, Zhimei Xiao, Liqiong Guo, Bi-jie Huang*. Health risk assessment for highway toll station workers exposed to PM2.5-bound heavy metals. Atmospheric Pollution Research. 2019, 10(4):1024-1030.

(13) Na Zheng, Shanjun Song, Xinglong Jin, Hongyan Jia, Yan Wang, Yaqin Ji, Liqiong Guo, Penghui Li, Assessment of Carbonaceous Aerosols at Mount Tai, North China: Secondary Formation and Regional Source Analysis. Aerosol and Air Quality Research. 2019, 19: 1708-1720.

(14) Juan Liu, Hui-Yu Wang, Shan-Jun Song, Hui-Chun Ma, Wen-Tao Sun, Lei Wang, Yan Wang, Xian-Liang Yi, Li-Qiong Guo, Peng-Hui Li, Levels, Potential Sources and Risk Assessment of Organochlorine Pesticides in Atmospheric Particulate Matter at Regional Background Site. Aerosol and Air Quality Research. 2019, 19: 2008-2016.

(15) Octavio Jiménez-Garza#*, Liqiong Guo, Hyang-Min Byun, Mariella Carrieri, Giovanni Battista Bartolucci, Briscia SocorroBarrón-Vivanco, Andrea A. Baccarellie. Aberrant promoter methylation in genes related to hematopoietic malignancy in workers exposed to a VOC mixture. Toxicol Appl Pharmacol. 2018, 339: 65-72.

(16) Octavio Jiménez-Garza#*, Liqiong Guo, Hyang-Min Byun, Mariella Carrieri, Giovanni Battista Bartolucci, Jia Zhong, Andrea A. Baccarellie. Promoter methylation status in genes related with inflammation, nitrosative stress and xenobiotic metabolism in low-level benzene exposure: Searching for biomarkers of oncogenesis. Food Chem Toxicol. 2017 Nov;109(Pt 1):669-676.

(17) Hong-yan Jia, Lei Wang, Peng-hui Li*, Yan Wang*, Li-qiong Guo, Tao Li, Lei Sun, You-ping Shou, Tian-yu Mao, Xian-liang Yi, Characterization, long-Range transport and source identification of carbonaceous aerosols during spring and autumn periods at a high mountain site in south China. Atmosphere, 2016,7: atmos7100122

(18) Peng-Hui Li*, Yan Wang*, Tao Li, Lei Sun, Xianliang Yi, Li-qiong Guo, Rui-hong Su, Characterization of carbonaceous aerosols at Mount Lu in South China: implication for secondary organic carbon formation and long-range transport. Environment Science and Pollution Research, 2015, 22: 14189-14199

(19) Akin Cayir, Timothy M. Barrow, Hao Wang, Hongbin Liu, Changping Li, Ning Ding, Yan Li, Choong-Min Kang, Liqiong Guo, Peng-hui Li*, Hyang-Min Byun, Occupational noise exposure is associated with hypertension in China: Results from project ELEFANT. Plos One, 2018, 13(12): e0209041

(20) Yu-jie Zhao, You-ping Shou, Tian-yu Mao, Li-qiong Guo, Peng-hui Li*, Xianliang Yi, Qian-qian Li, Li-zhu Shen, Huan-rong Zuo, Jing Wang, Lei Wang, PAHs exposure assessment for highway toll station workers through personal particulate sampling and urinary biomonitoring in Tianjin, China. Polycyclic Aromatic Compounds, 2016, DOI: 10.1080/10406638.2016.1220959

(21) Lifang Hou#*, Xiao Zhang#, Yinan Zheng, Sheng Wang, Chang Dou, Liqiong Guo, Hyang-Min Byun, Valeria Motta, John McCracken, Anaite Diaz, Choong-Min Kang, Petros Koutrakis, Pier Alberto Bertazzi, Jingyun Li, Joel Schwartz, Andrea A. Baccarelli. Altered Methylation in Tandem Repeat Element and Elemental Component Levels in Inhalable Air Particles. Environ Mol Mutagen, 2013. 55(3): 256-265.

(22) Jun-Jie Yue, Roberta Palmiero, Yang-Yang Han, Yan Wang, Qian-Qian Li, Tuo-Yu Zhang, Meiqing Sun, Hong Wang, Guangping Yu, Xian-Liang Yi, Peng-Hui Li*, Ya-Qin Ji*, Li-Qiong Guo, Characterization of PM1-bound Metallic Elements in the Ambient Air at a High Mountain Site in Northern China. Aerosol and Air Quality Research, 2018, 18:2967-2981

(23) Jing Liu, Yan Wang, Peng-Hui Li*, You-Ping Shou*, Tao Li, Min-Min Yang, Lei Wang, Jun-Jie Yue, Xian-Liang Yi, Li-Qiong Guo, Polycyclic Aromatic Hydrocarbons (PAHs) at High Mountain Site in North China: Concentration, Source and Health Risk Assessment. Aerosol and Air Quality Research, 2017, 17: 2867-2877

(24) Juan Liu, Hui-Yu Wang, Shan-Jun Song, Hui-Chun Ma, Wen-Tao Sun, Lei Wang*, Yan Wang, Xian-Liang Yi, Li-Qiong Guo, Peng-Hui Li*, Levels, potential sources and risk assessment of organochlorine pesticides in atmospheric particulate matter at regional background site. Aerosol and Air Quality Research, 2019, 19 (9), 2008-2016.

(25) Duan Ju, Xiao-Zhou Li, Yun-Fang Shi, Yan Li, Li-Qiong Guo, Ying Zhang*, Cytomegalovirus shedding in seropositive healthy women of reproductive age in Tianjin, China. Epidemiology and Infection, 2020, 148 (e34): 1-7

(26) Zhen XuXiaodong LiDan TianZhuoyu SunLiqiong GuoCuixia DongNaijun TangHermine V Mkrtchyan*, Molecular characterization of methicillin-resistant and -susceptible Staphylococcus aureus recovered from hospital personnel. Journal of Medical Microbiology. 2020 Nov 12.

 doi: 10.1099/jmm.0.001272. Online ahead of print.



【主要参与完成科研项目】

  1. 国家自然科学基金面上项目,81971416,血小板mtDNA甲基化与不明原因复发性流产的巢式病例对照研究,2020/01-2023/12,550,000,在研,主持

  2. 国家自然科学基金青年基金,81602827,血小板mtDNA甲基化作为PM暴露的易感性生物标志物的探索性研究,2017/01-2019/12,180,000,已结题,主持

  3. 天津市自然科学基金青年基金,18JCQNJC11700,线粒体DNA甲基化作为PM2.5暴露致心血管疾病的新型生物标志物的研究,2018/04-2021/03,60,000,在研,主持

  4. 天津医科大学基金,2010KY28,青年人群多环芳烃暴露的新型表观遗传标志物研究,2015/12-2017/11,10,000,已结题,主持

  5. 国家自然科学基金专项项目,81941024,基于遗传与环境交互作用调控线粒体功能对长寿的影响和机制研究,2020/01-2022/12,1,000,000,在研,参加;(第二)

  6. 国家自然科学基金面上项目,81872586,大气污染影响先天性心脏病发生的出生队列研究,2019/01-2022/12,570,000,在研,参加;(第四)

  7. 天津市科技计划项目,18ZXDBSY00190,基于新型标志物“不明原因复发性流产”风险预测模型的建立及评估——前瞻性队列研究,2018/10-2021/09,500,000,在研,参加;(第三)

  8. 国家自然科学基金青年基金,81602826, 出生前DEHP暴露对大鼠下丘脑能量平衡调控的影响及其机制研究,2017/01-2019/12,170,000,已结题,参加;(第二)

  9. 国家自然科学基金青年基金,81602850,基于海马Notch信号通路的高脂饮食诱导认知障碍的机制研究,2017/01-2019/12,180,000,已结题,参加;(第三)

  10. 国家自然科学基金青年基金,41601548,基于表观遗传学方法评估大气细颗粒物对人体心血管疾病的健康效应,2017/01-2019/12,190,000,已结题,参加;(第二)

  11. 天津市自然科学基金青年基金,17JCQNJC10300,天津地区大气环境中有机磷酯阻燃剂的分布特征、来源解析及人群暴露风险评价研究,2017/04-2020/03,60,000,已结题,参加;(第二)


 

 

 

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