龚燕华

 

职称:教授

邮箱:gongyanhua@tju.edu.cn

电话:022-87370177-210

地址:天津大学灾难医学研究院10号东配楼210

 

个人简介

龚燕华,男,197712月生于江苏省海门,博士,教授,博导。主要从事医学分子生物学与灾难医学生物救治研究。国家科技部“863计划”、国家重点研发计划项目、国家自然科学基金项目和军队后勤项目课题负责人。全军生物化学专业委员会常委。军队优秀专业技术人才二类岗位津贴获得者。

教育背景

2001.9-2005.11中国协和医科大学(北京协和医学院),生物化学与分子生物学,博士(直博,提前毕业)

1996.9-2001.7,华中科技大学同济医学院,临床医学系,学士

工作经历

2019.1-至今 天津大学灾难医学研究院,教授

2013.12-2018.12 中国人民武装警察部队后勤学院,卫生勤务系人体机能学教研室,主任、教授

2011.9-2013.11 中国人民武装警察部队后勤学院,临床医学系生物化学与分子生物学教研室主任、副教授

2010.4-2011.8 中国人民武装警察部队医学院(特招入伍),基础部生物化学与分子生物学教研室,主任、副教授 

2008.7-2010.3 中国医学科学院,基础医学研究所生化系,副研究员、硕士生指导教师(北京协和医学院第十八批研究生导师)

2005.12-2008.6 中国医学科学院,基础医学研究所生化系,助理研究员

代表性学术成果

【期刊论文】

1. Gong Yanhua, Wang Xu, Liu Jin, Shi Lei, Yin Bin, Peng Xiaozhong, Qiang Boqin & Yuan Jiangang NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183. FEBS lett, 2005, 579(1), 115-121 (IF:3.83)

2. Yan-hua Gong, Ji-Ping Yue, Xu-Dong Wu, Xu Wang, Jian-Yan Wen, Xiaozhong Peng, Jiangang Yuan, Boqin Qiang. NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element. Nucleic Acid Res2006,34(21): 6158-69. (IF:11.561)

3. Xiuhua Dong, Feng Xu, Yanhua Gong, Feng Wang, Jin Gao, Xiaozhong Peng, Jiangang Yuan, Boqin Qiang, Zihe Rao, Crystal Structure of the First Domain of Human Nectin-like Molecule-1/ TSLL1/ SynCAM3, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. J Biol Chem., 2006,281(15):10610-7 (IF: 5.854)

4. Lei Shi, Jiping Yue, Yuangang You, Bin Yin, Yanhua Gong, Caimin Xu, Boqin Qiang, Jiangang Yuan, Yongjian Liu*, and Xiaozhong Peng*. Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation. Cellualr Signalling. 2006,18(11):1995-2003(IF: 4.887)

5Xingqi Yan, Tengfei ChaoKang Tu , Yu Zhang , Lu Xie, Yanhua Gong, Jiangang Yuan*, Boqin Qiang, Xiaozhong Peng*  Improving the prediction of human microRNA target genes by using combined SVM based algorithm. FEBS lett. 2007, 581,1587–1593 (IF:3.83)

6.Jianyan Wen, Qing Xia, Cailing Lu, Lina Yin, Juan Hu, Yanhua Gong, Bin Yin, Koshiro Monzen, Jiangang Yuan, Boqin Qiang, Xuemin Zhang, Xiaozhong Peng*  Proteomic analysis of cardiomyocytes differentiation in mouse embryonic carcinoma P19CL6 cells. J Cell Biochem. 2007,102(1):149-60 (IF:3.871)

7. Yanhua Gong, Jing Wu, Hua Qiang , Ben Liu, Zhikai Chi, Tao Chen, Bin Yin, Xiaozhong Peng & Jiangang Yuan. BRI(3) Associates with SCG10 and Attenuates NGF-induced Neurite Outgrowth in PC12 Cells. BMB Reports. 2008,41(4):287-93 (IF:3.089)

8.Xudong Wu, Yanhua Gong, Jiping Yue, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng . Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing. Nucleic Acids Research,2008,36(11):3590-3599 (IF:11.561)  

9.Fengwei Tan , Lifang Lu , Yun Cai, Jinglan Wang, Lin Wang, Yanhua Gong , Bing-e Xu, Jun Wu, Ying Luo, Boqin Qiang, Jiangang Yuan, Xiaoqing Sun, and Xiaozhong Peng. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. Proteomics. 2008,8(14):2885-96 (IF:5.735)

10.Jing Gao, Tao Chen, Guangyu Hu, Yanhua Gong, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng. Nectin-like molecule 1 is a glycoprotein with a single N-glycosylation site at N290KS which influences its adhesion activity. BBA-Biomembranes 2008, 17781429–1435 (IF: 4.18)

11.Chen Y, Liu W, Chao T, Zhang Y, Yan X, Gong Y, Qiang B, Yuan J, Sun M, Peng X. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. Cancer Lett. 2008,272(2):197-205. (IF: 6.491)

12Zheng G, Liu W, Gong Y, Yang H, Yin B, Zhu J, Xie Y, Peng X, Qiang B, Yuan J.Human D-Tyr-tRNATyr deacylase contributes to cell's resistance to D-amino acids. Biochem J. 2009,417(1):85-94 (IF: 4.371)

13: Jing Gao, Tao Chen, Guangyu Hu, Jin Liu, Yanhua Gong, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng. NECL1, a novel glioma repressor can be reexpressed by TSA treatment in glioma cell lines. Glia 2009,57(9):989-99 (IF: 6.209)

14.Yu Zhang, Tengfei Chao, Ran Li, Wei Liu, Wei Liu,Yang Chen, Xingqi Yan, Jizhong Zhao, Yanhua Gong, Bin Yin, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. J. Mol. Med. 2009,87(1):43-51. (IF:4.82)  

15.LIU Wei*, GONG Yan-hua* Identification of differentially expressed microRNAs by microarray: a possible role for microRNAs gene in medulloblastomas , CHAO Teng-fei, PENG Xiao-zhong, YUAN Jian-gang, MA Zhen-yu, JIA Ge and ZHAO Ji-zong C.M.J. 2009,122(20): 2405-2411 (IF: 1.064)

16.Xianping Wang, Zhiyong Lou, Xiuhua Dong, Wen Yang,Yong Peng, Bin Yin, Yanhua Gong, Jiangang Yuan, Weihong Zhou,Mark Bartlam, Xiaozhong Peng and Zihe Rao Crystal Structure of the C-Terminal Domain of Human DPY-30-Like Protein: A Component of the Histone Methyltransferase Complex J. Mol. Biol. 2009,390: 530–537

17.Jianyan Wen, Qing Xia, Wei Liu, Yang Chen, Jing Gao, Yanhua Gong, Yuannan Ke, Boqin Qiang , Jiangang Yuan , Xiaozhong Peng Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway. J. Mol. Cell. Cardiol. 2009, 47(6): 761-769 (IF: 5.682)

18.Yuangang You; Weiqi Li; Yanhua Gong; Bin Yin; Boqin Qiang; Jiangang Yuan; Xiaozhong PengShcD interacts with TrkB via its PTB and SH2 domains and  regulates BDNF-induced MAPK activation . BMB Reports 2010,437:485-90 (IF3.089)

19Weiqi Li*, Lei Shi*, Yuangang You, Yanhua Gong, Bin Yin, Jiangang Yuan, Xiaozhong Peng Dok6as a novel substrate of TrkC receptor, exerted pivotal roles in NT-3 mediated neurite outgrowth of mice cortex cells BMC Biology 2010, 8:86 (IF: 6.779)

20Wei Liu*, Chang Liu*, Jingxi Zhu, Pengcheng Shu ,Bin Yin, Yanhua Gong, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng  microRNA-16 targets APP to potentially modulate AD pathogenesis in SAMP8 mice Neurobiology of Aging, 2012,33: 522–534 (IF: 5.959)

21. Wang R M, Liu Z Z, Gong Y H, Chen L J, Jia Q, Wang Y J, Fang F, Lv H, Zhang G J, Kang X X. Association analysis of USF1 gene polymorphisms and total unstable carotid plaque area in atherosclerotic stroke patients. J Thromb Thrombolysis, 20133: 317-23

22. Hui Li, Rong Fan, Mingze Sun, Tao Jiang, Yanhua Gong* Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4.Biochemical and Biophysical Research Communications,2013, 440: 527-532 (IF: 2.985)

23.Yuheng Shan, Xian Chen, Yanchen Lin, Yuliang Wang, Shijiang Zhong*, Yanhua Gong*Value of magnetic resonance spectroscopy and perfusion-weighted imaging in distinguishing glioma recurrence from PTRE: a meta-analysis Int J Clin Exp Med 2016,9(6):10006-10017 (IF:1.069)

24.Shijiang ZhongYanhua Gong, Yanchen LinCombined  intranasal  nerve  growth  factor  and  ventricle  neural  stem cell  grafts  prolong  survival  and  improve  disease  outcome in amyotrophic  lateral  sclerosis  transgenic  mice. Neuroscience Letters, 2017,656:1–8 (IF: 2.274)

25.Yuliang Wang , Zhikong Liang , Hui Li, Jinglong Tao, Yi Sun ,Yanhua Gong.NSPc1 polycomb protein complex binds and cross-talks to lncRNAs in glioma H4 cells. Oncology Reports, 2019,414:2575-2584 (IF:3. 417)  

26.Zhikong Liang , Yuliang Wang , Hui Li, Yi Sun* ,Yanhua Gong*. LncRNAs combine and crosstalk with NSPc1 in ATRA induced differentiation of U87 glioma cells. Oncology Letters,2019,17: 5821-5829 (IF: 2.311)

27.Cai Wei#; Liu Ziquan#; Li Guangzong; Xiao Peixin; Lv Qi; Gong Yanhua; Fan Haojun; Hou Shike*; Ding Hui*; The effects of a graded increase in chronic hypoxia exposure duration on healthy rats at high-altitude, International Journal of Clinical and Experimental Pathology, 2019,12(6): 1975-1991.

28. Weizhou Wu, Shijiang Zhong, Yanhua Gong, Yuheng Shan, LiNa Yuan, Li Wang, Jian Chen* , Zhe Zhang*A new molecular probe: An NRP-1 targeting probe for the grading diagnosis of glioma in nude mice. Neurosci Lett. 2020;714:134617 (IF: 2.274)

29.Mengyang Yu , Qi Lv , Jie Shi , Yahua Liu , Haojun Fan , Hui Ding , Ziquan Liu , Juan Cao , Yanhua Gong , Shike Hou.β1-Blocker improves survival and ventricular remodelling in rats with lethal crush injury. Eur J Trauma Emerg Surg. 2020;10.1007/s00068-020-01408-y. (IF: 2.139)

30. Ning Li, Xinyue Wang, Pengtao Wang, Haojun Fan, Shike Hou*, Yanhua Gong*. Emerging medical therapies in crush syndrome-progress report from basic sciences and potential future avenues, Renal Failure, 2020;42:1, 656-666 (IF:1.985)

31.Ning Li, Chenhao Geng, Shike Hou, Haojun Fan*, Yanhua Gong*.Damage-Associated Molecular Patterns and Their Signaling Pathways in Primary Blast Lung Injury: New Research Progress and Future Direction. International Journal of Molecular Sciences2020; 21, 6303; doi:10.3390/ijms21176303 (IF: 4.556)

32.NingLi, Pengtao Wang, Xinyue Wang, Chenhao Geng, Jiale Chen, Yanhua Gong*. Molecular diagnosis of novel coronavirus pneumonia: current situation and trend. Experimental and Therapeutic Medicine2020; 20(5):1-1DOI: 10.3892/etm.2020.9142 (IF: 1.785)





【承担科研项目】



1、国家重点研发计划项目(课题),2019YFC1606304,突发重特大自然灾害事件食品安全应急保障技术体系集成与应用,2019 /12- 2022 /12 ,326万(自筹经费1500万),在研,主持。

2、天津大学“双一流大学”人才项目,挤压综合征急性肾损伤的生物救治研究平台,2019/01-2020/12,80万,在研,主持。

3、中央军委科技委创新项目,C12019048, 2019/06-2020/12,200万,在研,子课题负责人。

4、国家自然科学基金面上项目,81370439microRNA-206靶向ZFP580调控球囊损伤后平滑肌细胞表型转换的分子机制,2014/01-2017/1265万元,已结题,第二承担人。

5、武警总部科研项目,WJHQ2012-13NSPc1在部队作业辐射损伤过程中对机体保护作用的机制研究,2013/01-2015/1218万元,已结题,主持。

6、国家自然科学基金青年项目,81201757,多梳家族成员NSPc1对脑胶质瘤干细胞辐射抗性的调控作用及机制研究,2013/01-2015/1223万元,已结题,第二承担人。

7、国家自然科学基金面上项目,31070929NSPc1 调控小鼠神经干细胞体外增殖与分化的分子机制,2011/01-2013/1234万元,已结题,主持。

8、国家科技部973计划,2006CB504100,高原低氧等环境因素损伤适应机理与干预措施 (子课题:神经缺氧与分化的关系),2006/09-2011/09,50万元,已结题,子课题负责人。

9、国家自然科学基金项目(主任基金),30971614,干细胞中表观抑制因子NSPc1 的调控作用,2010/01-2010/128万元,已结题,主持。

10、国家自然科学基金青年项目,30600166,神经系统多梳蛋白NSPc1抑制转录与促细胞增殖的表观调控机制,2007/01-2009/1230万元,已结题,主持。

11、国家科技部863计划项目(探索导向类),2006AA02Z137,神经肿瘤细胞分化相关蛋白网络调控节点的识别和筛选,2006/12-2008/1290万元,已结题,主持。

【专著】

1.    《基因组2 2006年,科学出版社,参译

2.    《基因组3 2009年,科学出版社,参译

3.    《蛋白质相互作用及亚细胞定位原理与技术》 2010年,中国协和医科大学出版社,主编

4.    《医学分子生物学》 2011年,人民军医出版社,副主编

5.    《人体功能学》 2012年,人民军医出版社,副主编

6.   《中国灾难医学高级教程》,2019年,华中科技大学出版社,参编

 

 

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